PROJECTS A: Protein engineering of esterases

Jessica Moisan is involved with the identification of structural features that determine esterase behavior.  Her goal is to decipher the contribution of surface and buried salt bridges in an extremely stable esterase named EstGtA2 (from Geobacillus thermodenitrificans).  

Ximena Zottig carries pioneering work on a novel esterase from Aneurinibacillus thermoaerophilus.  The comparison of this enzyme with previously characterized ones sheds light on phylogenetic relationships among bacterial esterases and the control of thermostability.